Potassium Carbonate → HCID 20309447, compound

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Reaction Steps

A stirred mixture of 3-chloro-6-(2-hydroxy-4-methoxyphenyl)pyridazine (0.1 mole), potassium carbonate (0.3 mole) and epibromohydrin (0.4 mole) in butan-2-one was heated under reflux overnight. The filtered solution was evaporated to give an oil which was purified by elution with mixtures of chloroform-methanol on a silica column to give 3-chloro-6-[2-(2,3-epoxypropoxy)-4-methoxyphenyl]pyridazine m.p. 111°-112° (ethanol).

Provenance & Evidence