Hydrazine hydrate (1:1) → HCID 20309455, compound

HRID 1763229Notes

Reaction equation

HRID 1763229 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:23]=[N:22][C:21]([Cl:24])=[CH:20][CH:19]=1)([CH3:4])([CH3:3])[CH3:2].O.[NH2:27][NH2:28]>>[ClH:24].[ClH:24].[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:23]=[N:22][C:21]([NH:27][NH2:28])=[CH:20][CH:19]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309446HCID 20309446, compound

Product 1

HCID 20309455HCID 20309455, compound

Procedure

A stirred mixture of hydrazine hydrate (30 ml) and 6-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-3-chloropyridazine (2.9 g) was heated under reflux for 5 hours, and was cooled to 0°. The oil which separated out was dissolved in chloroform and this solution was washed with water, and with dilute hydrochloric acid, and evaporated to give 3-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-6-hydrazinopyridazine dihydrochloride, m.p. 240°-245° (methanol)

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. temperaturewas cooled to 0°
  4. customThe oil which separated out
  5. dissolutionwas dissolved in chloroform
  6. washthis solution was washed with water
  7. customwith dilute hydrochloric acid, and evaporated

Sources & evidence

ORD record
ord-55eff04a46784ca68d0805158a452c07
Source dataset
uspto-grants-1978_09
Patent number
US04111935

Reaction notes

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