Hydrazine hydrate (1:1) → HCID 135731742, compound

HRID 1763232Notes

Reaction equation

HRID 1763232 reaction equation
O.[NH2:2][NH2:3].[OH:4][C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[C:7]([CH2:9][CH2:10][C:11](O)=[O:12])=O>O>[OH:4][C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[C:7]1[CH2:9][CH2:10][C:11](=[O:12])[NH:2][N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 30160863-(2-Hydroxybenzoyl)propionic acid

Product 1

HCID 135731742HCID 135731742, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Hydrazine hydrate (1.2 ml) was added to a stirred suspension of 3-(2-hydroxybenzoyl)propionic acid (3.1 g) in water (20 ml), and the mixture was heated under reflux for 3/4 hour. The mixture was diluted with an equal volume of water, allowed to cool, and filtered to give 6-(2-hydroxyphenyl)-4,5-dihydro-3(2H)pyridazinone (2.6 g) m.p. 211°-212°.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3/4 hour
  3. temperatureto cool
  4. filtrationfiltered

Sources & evidence

ORD record
ord-a30788da928c40afbe0b2559096d8de0
Source dataset
uspto-grants-1978_09
Patent number
US04111935

Reaction notes

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