Tert-Butylamine → 1-(tert-Butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol

Participants

Reaction Steps

A mixture of 3-chloro-6-(2-epoxypropoxyphenyl)pyridazine (0.7 g), methanol (7 ml) and t-butylamine (1.7 ml) was stirred and heated under reflux for 11/4 hours. The mixture was evaporated under reduced pressure at 50° and the residue was recrystallised from toluene to give the title product (1.28 g) m.p. 136.5°-137.5°.

Provenance & Evidence