Tert-Butylamine → 1-(tert-Butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol

HRID 1763237Notes

Reaction equation

HRID 1763237 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]2[O:18][CH2:17]2)=[CH:6][CH:7]=1.[C:19]([NH2:23])([CH3:22])([CH3:21])[CH3:20]>CO>[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]([OH:18])[CH2:17][NH:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 13023013HCID 13023013, compound

Product 1

HCID 30190301-(tert-Butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3-chloro-6-(2-epoxypropoxyphenyl)pyridazine (0.7 g), methanol (7 ml) and t-butylamine (1.7 ml) was stirred and heated under reflux for 11/4 hours. The mixture was evaporated under reduced pressure at 50° and the residue was recrystallised from toluene to give the title product (1.28 g) m.p. 136.5°-137.5°.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 11/4 hours
  3. customThe mixture was evaporated under reduced pressure at 50°
  4. customthe residue was recrystallised from toluene

Sources & evidence

ORD record
ord-545fc2ce118a4cd19a8cb5bf2be66a17
Source dataset
uspto-grants-1978_09
Patent number
US04111935

Reaction notes

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