Sodium Hydroxide → Pyridine, 2,3,5-trichloro-

To a 5-liter 3-neck flask fitted with a reflux condenser, a heater, thermometer and a stirrer were added 216.9 grams (1.0 mole) of 2,3,5,6-tetrachloropyridine, 500 milliliters of benzene, 1.0 liter of 8N sodium hydroxide and 130.7 grams (2.0 gram atoms) of zinc dust. The pH of the mixture was 14-15 and the mixture was heated and refluxed, with stirring, for 7 hours. After completion of the reaction, the reaction mixture was cooled and filtered. The filter cake was washed with benzene and the benzene wash was combined with the filtrate. Gas-liquid chromatography of the mixture indicated a 2,3,5-trichloropyridine content of about 131.35 grams (72 percent of theoretical).

1. customTo a 5-liter 3-neck flask fitted with a reflux condenser
2. temperaturethe mixture was heated
3. temperaturerefluxed
4. customAfter completion of the reaction
5. temperaturethe reaction mixture was cooled
6. filtrationfiltered
7. washThe filter cake was washed with benzene
8. washthe benzene wash

ORD record

ord-2ab1497643c248ce908a897cd9ec7589

Source dataset

uspto-grants-1978_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04111938