Hydrochloric Acid → HCID 20309706, compound

HRID 1763282Notes

Reaction equation

HRID 1763282 reaction equation
[C:1]1(=[O:20])[N:6]([C:7]2[CH:8]=[C:9]([CH:13]=[C:14]([N+:16]([O-])=O)[CH:15]=2)[C:10]([OH:12])=[O:11])[C:5](=[O:19])[CH2:4][CH2:3][CH2:2]1.[OH-:21].[Na+].Cl>[Pd]>[C:10]([C:9]1[CH:8]=[C:7]([CH:15]=[C:14]([NH2:16])[CH:13]=1)[NH:6][C:5](=[O:19])[CH2:4][CH2:3][CH2:2][C:1]([OH:20])=[O:21])([OH:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20309632HCID 20309632, compound

Product 1

HCID 20309706HCID 20309706, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-Glutarimido-5-nitrobenzoic acid (55.6 g.) was dissolved in 150 ml. of 10% aqueous sodium hydroxide, the pH adjusted to 8 with 3N hydrochloric acid, 1.0 g. of 10% palladium-on-carbon catalyst added, and the mixture hydrogenated in a Parr apparatus. Reduction was complete in 5 hours. The reaction mixture was filtered and the filtrate containing 3'-carboxy-5'-aminoglutaranilic acid iodinated as described below.

Workup

  1. filtrationThe reaction mixture was filtered
  2. additionthe filtrate containing 3'-carboxy-5'-aminoglutaranilic acid iodinated

Sources & evidence

ORD record
ord-4409f25cf6d0480284e8ef587708dca1
Source dataset
uspto-grants-1978_09
Patent number
US04111937

Reaction notes

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