Hydrazine hydrate (1:1) → HCID 70615240, compound

HRID 1763306Notes

Reaction equation

HRID 1763306 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:11]=1[C:12]([CH2:14][CH2:15][C:16](OC)=[O:17])=O)([CH3:4])([CH3:3])[CH3:2].O.[NH2:27][NH2:28]>>[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:11]=1[C:12]1[CH2:14][CH2:15][C:16](=[O:17])[NH:27][N:28]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309571HCID 20309571, compound

Product 1

HCID 70615240HCID 70615240, compound

Procedure

Methyl 3-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methylbenzoyl]propionate was cyclised with hydrazine hydrate in a manner similar to that described in Example 2(ii) to give 6-[2-(3 -t-butylamino-2-hydroxypropoxy)-4-methylphenyl]-4,5-dihydro-3(2H)-pyridazinone (m.p. 129.5°-130.5° C). The hydrochloride, crystallised from ethanol-ether, had m.p. 206.5°-209.5° C.

Sources & evidence

ORD record
ord-64283779b2144195af02f25c53a0b262
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

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