Hydrochloric Acid → HCID 20309489, compound

HRID 1763307Notes

Reaction equation

HRID 1763307 reaction equation
Cl.[Cl:2][C:3]1[CH:15]=[CH:14][C:6]([C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])=[C:5]([OH:16])[CH:4]=1.[CH2:17](O)[CH3:18]>>[Cl:2][C:3]1[CH:15]=[CH:14][C:6]([C:7]([CH2:9][CH2:10][C:11]([O:13][CH2:17][CH3:18])=[O:12])=[O:8])=[C:5]([OH:16])[CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20309460HCID 20309460, compound

Product 1

HCID 20309489HCID 20309489, compound

Procedure

Hydrogen chloride was bubbled into a gently boiling solution of 3-(4-chloro-2-hydroxybenzoyl)propionic acid (12.0 g, 0.053 mole) in dry ethanol (21.2 cc) until esterification was complete. The product crystallised from ether to give ethyl 3-(4-chloro-2-hydroxybenzoyl)-propionate (13.29 g, 98% m.p. 68°-69° ) (Found: C, 56.07; H, 5.06; Cl, 13.69; M+, 256/258. C12H13ClO4 requires: C, 56.15; H, 5.10; Cl, 13.81%; M, 256/258).

Workup

  1. customThe product crystallised from ether

Sources & evidence

ORD record
ord-f7b26f8e0c6740929e60c1e6aec92521
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

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