Hydrazine hydrate (1:1) → HCID 20309526, compound

HRID 1763326Notes

Reaction equation

HRID 1763326 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=1[C:19](=O)[CH2:20][CH2:21][C:22](O)=[O:23])([CH3:4])([CH3:3])[CH3:2].O.[NH2:28][NH2:29]>O>[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=1[C:19]1[CH2:20][CH2:21][C:22](=[O:23])[NH:29][N:28]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309559HCID 20309559, compound

Product 1

HCID 20309526HCID 20309526, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of equimolar amounts of 4-(3-t-butylamino-2-hydroxypropoxy)-3-(3-carboxypropionyl)benzoic acid and hydrazine hydrate in water was heated under reflux for 16 hours. The volume of the solution was reduced in vacuo to give 4-(3-t-butylamino-2-hydroxypropoxy)-3-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)benzoic acid.

Workup

  1. temperatureunder reflux for 16 hours

Sources & evidence

ORD record
ord-ac62c8b19f9d424a89c5203169bbb0d5
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

Loading…