Hydrazine hydrate (1:1) → HCID 20309514, compound

HRID 1763333Notes

Reaction equation

HRID 1763333 reaction equation
[C:1]([NH:5][CH:6]([CH2:23][OH:24])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[C:16]1[CH:17]=[CH:18][C:19](=S)[NH:20][N:21]=1)([CH3:4])([CH3:3])[CH3:2].O.[NH2:26][NH2:27]>>[C:1]([NH:5][CH:6]([CH2:23][OH:24])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[C:16]1[N:21]=[N:20][C:19]([NH:26][NH2:27])=[CH:18][CH:17]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309555HCID 20309555, compound

Product 1

HCID 20309514HCID 20309514, compound

Procedure

6-[2-(2-t-Butylamino-3-hydroxypropoxy)-5-methylphenyl]-3(2H)-pyridazinethione was treated with hydrazine hydrate in a similar manner to the procedure described in Example 2 (vi) to give 3-[2-(2-t-butylamino-3-hydroxypropoxy)-5-methylphenyl]-6-hydrazinopyridazine as an oil which was isolated as the hemisulphate, m.p. 172°-178° C. (Found: C, 54.6; H, 7.1; N, 17.5; S, 3.9% C18H27N5O2. 0.5H2SO4 requires: C, 54.8; H, 7.2; N, 17.8; S, 4.1%

Sources & evidence

ORD record
ord-ed62ba3e31d7424d9d825c77a4ff063f
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

Loading…