Tert-Butylamine → HCID 20309482, compound

HRID 1763339Notes

Reaction equation

HRID 1763339 reaction equation
[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:6]=1[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8].[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>>[C:22]([NH:26][CH2:21][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:6]=1[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:25])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 20309580HCID 20309580, compound

Product 1

HCID 20309482HCID 20309482, compound

Procedure

Methyl 3-[2-(2,3-epoxypropoxy)-5-methoxybenzoyl]-propionate was reacted with t-butylamine in a similar manner to that described in Example 2 (i) to give methyl 3-[2-(3-t-butylamino-2-hydroxypropoxy)-5-methoxybenzoyl]-propionate, which recrystallised from ether, had m.p. 70° - 72° C. (Found: C, 62.22; H, 8.22; N, 3.65; C19H29NO6 requires: C, 62.10; H, 7.96; N, 3.81%)

Sources & evidence

ORD record
ord-786dfa9b1b5d453098497899808b9bf6
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

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