反应详情

N-methyl piperazine (2 g) is dissolved in 80 ml chloroform, and mixed with a solution of 3.22 g 3,3,3-trichloropropylene oxide in 20 ml chloroform. The mixture is allowed to stand at room temperature for 6 days. The chloroform is removed by evaporation, and ether is added to the residue, which is then collected by filtration, washed with ether and dried at room temperature under water pump vacuum, to give the heading compound, m.p. 165°-167° C.

1. customThe chloroform is removed by evaporation, and ether
2. additionis added to the residue, which
3. filtrationis then collected by filtration
4. washwashed with ether
5. customdried at room temperature under water pump vacuum
6. customto give the heading compound, m.p. 165°-167° C.