2-(Trichloromethyl)oxirane → 1-Methyl-4-(3,3,3-trichloro-2-hydroxypropyl) piperazine

HRID 1763451Notes

Reaction equation

HRID 1763451 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Cl:8][C:9]([Cl:14])([Cl:13])[CH:10]1[O:12][CH2:11]1>C(Cl)(Cl)Cl>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:11][CH:10]([OH:12])[C:9]([Cl:14])([Cl:13])[Cl:8])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 183212-(Trichloromethyl)oxiraneHCID 531671-Methylpiperazine

Product 1

HCID 543882601-Methyl-4-(3,3,3-trichloro-2-hydroxypropyl) piperazine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

N-methyl piperazine (2 g) is dissolved in 80 ml chloroform, and mixed with a solution of 3.22 g 3,3,3-trichloropropylene oxide in 20 ml chloroform. The mixture is allowed to stand at room temperature for 6 days. The chloroform is removed by evaporation, and ether is added to the residue, which is then collected by filtration, washed with ether and dried at room temperature under water pump vacuum, to give the heading compound, m.p. 165°-167° C.

Workup

  1. customThe chloroform is removed by evaporation, and ether
  2. additionis added to the residue, which
  3. filtrationis then collected by filtration
  4. washwashed with ether
  5. customdried at room temperature under water pump vacuum
  6. customto give the heading compound, m.p. 165°-167° C.

Sources & evidence

ORD record
ord-b490b885b32b402ba6403496fd8f21ed
Source dataset
uspto-grants-1978_09
Patent number
US04112091

Reaction notes

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