Aminopyrazine → N-(2-pyrazinyl)-1-(4-methoxybenzyl)-1H-tetrazole-5-carboxamide

HRID 1763454Notes

Reaction equation

HRID 1763454 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[C:12]([C:13](Cl)=[O:14])=[N:11][N:10]=[N:9]2)=[CH:5][CH:4]=1.[NH2:18][C:19]1[CH:24]=[N:23][CH:22]=[CH:21][N:20]=1>C(Cl)Cl>[N:20]1[CH:21]=[CH:22][N:23]=[CH:24][C:19]=1[NH:18][C:13]([C:12]1[N:8]([CH2:7][C:6]2[CH:16]=[CH:17][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:9]=[N:10][N:11]=1)=[O:14]

Participants

4

Reactant 2

HCID 78747AminopyrazineHCID 204638701-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride

Product 1

HCID 20310358N-(2-pyrazinyl)-1-(4-methoxybenzyl)-1H-tetrazole-5-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(4-Methoxybenzyl)-1H-tetrazole-5-carbonyl chloride is reacted in methylene chloride with 2-aminopyrazine to obtain N-(2-pyrazinyl)-1-(4-methoxybenzyl)-1H-tetrazole-5-carboxamide. The protected intermediate is deprotected and worked up by the techniques described in Example 1 to yield the title compound.

Sources & evidence

ORD record
ord-05cc6f0f457f4585aea8d73efa089f18
Source dataset
uspto-grants-1978_09
Patent number
US04112094

Reaction notes

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