Pyridine → HCID 136388420, compound

HRID 1763463Notes

Reaction equation

HRID 1763463 reaction equation
C([C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:9][C:8]2=[O:17])(=O)C.Cl.N[OH:20].[N:21]1C=CC=[CH:23][CH:22]=1>>[OH:20][N:21]=[C:22]([C:5]1[CH:4]=[C:16]2[N:7]([C:8](=[O:17])[NH:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=32)[N:6]=1)[CH3:23]

Participants

4

Reactant 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 135735626HCID 135735626, compound

Product 1

HCID 136388420HCID 136388420, compound

Procedure

1.5 g (0.0066 mole) of 1-acetylpyrazolo[1,5-c]quinazolin-5(6H)-one and 2.8 g of hydroxylamine hydrochloride in pyridine are stirred overnight at room temperature. The reaction mixture is poured into 450 ml ice-water and stirred for 30 minutes. The fine white precipitates that form are filtered off, washed well with water and dried in vacuo at ~90° for 20 hours. Yield: 1.4 g, m.p. 340°-342°; 87.5%.

Workup

  1. customThe fine white precipitates that form
  2. filtrationare filtered off
  3. washwashed well with water
  4. customdried in vacuo at ~90° for 20 hours

Sources & evidence

ORD record
ord-7dff709467fd4988935c31bff119ddd2
Source dataset
uspto-grants-1978_09
Patent number
US04112098

Reaction notes

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