HCID 20381994, compound → HCID 135689266, compound

HRID 1763521Notes

Reaction equation

HRID 1763521 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:16]=[C:15]2[N:6]([C:7](=[O:26])[N:8](CC3C=CC(OC)=CC=3)[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=32)[N:5]=1>F>[CH3:1][O:2][CH2:3][C:4]1[CH:16]=[C:15]2[N:6]([C:7](=[O:26])[NH:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=32)[N:5]=1

Participants

3

Reactant 1

HCID 20381994HCID 20381994, compound

Product 1

HCID 135689266HCID 135689266, compound

Reagents, catalysts & solvents 1

HCID 14917Hydrofluoric AcidSolvent

Procedure

2.9 g (0.01 mole) of 2-(methoxymethyl)-6-(p-methoxybenzyl)pyrazolo[1,5-c]quinazolin-5(6H)-one in 100 ml of anhydrous hydrogen fluoride is stirred at 20° C. for one hour. The hydrogen fluoride is then evaporated; the residue is partitioned between methylene chloride and dilute aqueous sodium bicarbonate. The organic phase is washed with water, dried and evaporated. The residue is stirred with ether and the title compound is filtered off and dried.

Workup

  1. customThe hydrogen fluoride is then evaporated
  2. customthe residue is partitioned between methylene chloride and dilute aqueous sodium bicarbonate
  3. washThe organic phase is washed with water
  4. customdried
  5. customevaporated
  6. filtrationthe title compound is filtered off
  7. customdried

Sources & evidence

ORD record
ord-72920bc795d143a6bbe1502c2ea83db5
Source dataset
uspto-grants-1978_09
Patent number
US04112096

Reaction notes

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