Hydrochloric Acid → HCID 135737586, compound

HRID 1763522Notes

Reaction equation

HRID 1763522 reaction equation
C([O:8][C:9]1[CH:18]=[CH:17][C:16]2[NH:15][C:14](=[O:19])[N:13]3[N:20]=[C:21]([CH2:23][CH2:24][OH:25])[CH:22]=[C:12]3[C:11]=2[CH:10]=1)C1C=CC=CC=1.C(O)C.Cl.[H][H]>[Pd]>[OH:8][C:9]1[CH:18]=[CH:17][C:16]2[NH:15][C:14](=[O:19])[N:13]3[N:20]=[C:21]([CH2:23][CH2:24][OH:25])[CH:22]=[C:12]3[C:11]=2[CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 135737576HCID 135737576, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 135737586HCID 135737586, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

29.2 g (0.1 mole) of 9-(benzyloxy)-2-(2-hydroxyethyl)pyrazolo[1,5-c]quinazolin-5(6H)-one and 0.5 g 10% palladium-on-carbon in 200 ml ethanol containing 0.2 moles of hydrogen chloride are hydrogenated on a Parr shaker, with cooling, at ambient temperature. The reaction is stopped after 0.3 moles of hydrogen are absorbed or when hydrogen uptake ceases, whichever comes first. The reaction is diluted with chloroform, filtered and the filtrate evaporated. The residue is suspended in methylene chloride and shaken with excess aqueous sodium bicarbonate. The organic phase is washed with water, dried and evaporated to give the title compound.

Workup

  1. customare absorbed
  2. additionThe reaction is diluted with chloroform
  3. filtrationfiltered
  4. customthe filtrate evaporated
  5. washThe organic phase is washed with water
  6. customdried
  7. customevaporated

Sources & evidence

ORD record
ord-083fb58cd9924acd88326d67f62788e1
Source dataset
uspto-grants-1978_09
Patent number
US04112096

Reaction notes

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