Potassium Acetate → HCID 53983417, compound

HRID 1763536Notes

Reaction equation

HRID 1763536 reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[K+].Br[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][N:15]=1>C(O)(=O)C>[C:1]([O:4][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][N:15]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 20310541HCID 20310541, compound

Product 1

HCID 53983417HCID 53983417, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 12.5 g. potassium acetate (0.128 mole), 20.1 g. (0.064 mole) α-bromo-o-(5-phenyl-3-isoxazolyl)toluene and 200 ml. acetic acid is refluxed for 22 hours. The mixture is cooled and the acetic acid evaporated in vacuo. The residue is distilled on high vacuum and the fraction distilling at 140°-150° C. (0.25 mm) is collected and then crystallized from peteroleum ether containing a small amount of ether to give o-(5-phenyl-3-isoxazolyl)benzyl acetate; m.p. 50° to 62° C.

Workup

  1. additionA mixture of 12.5 g
  2. temperatureThe mixture is cooled
  3. customthe acetic acid evaporated in vacuo
  4. distillationThe residue is distilled on high vacuum
  5. distillationthe fraction distilling at 140°-150° C. (0.25 mm)
  6. customis collected
  7. customcrystallized from peteroleum ether containing a small amount of ether

Sources & evidence

ORD record
ord-c5162eaa4dda49feb7582c69706bd149
Source dataset
uspto-grants-1978_09
Patent number
US04112108

Reaction notes

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