Sodium Hydroxide → HCID 54167400, compound

HRID 1763537Notes

Reaction equation

HRID 1763537 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:14][N:13]=1)(=O)C.[OH-].[Na+]>C(O)C>[C:17]1([C:15]2[O:14][N:13]=[C:12]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[CH2:5][OH:4])[CH:16]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53983417HCID 53983417, compound

Product 1

HCID 54167400HCID 54167400, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of o-(5-phenyl-3-isoxazolyl)benzyl acetate, 35.2 ml. (0.352 mole) of 1 N sodium hydroxide solution and 95 ml. of ethanol is stirred for 4 days at room temperature. The ethanol is removed in vacuo and the aqueous material extracted with methylene chloride. The methylene chloride is washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo. The residue is crystallized from ether/petroleum ether to give o-(5-phenyl-3-isoxazolyl) benzyl alcohol; m.p. 68° to 70° C.

Workup

  1. customThe ethanol is removed in vacuo
  2. extractionthe aqueous material extracted with methylene chloride
  3. washThe methylene chloride is washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated in vacuo
  7. customThe residue is crystallized from ether/petroleum ether

Sources & evidence

ORD record
ord-5a9fa3a3bc014e7b8b03b9ab8fb1c31a
Source dataset
uspto-grants-1978_09
Patent number
US04112108

Reaction notes

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