Acetohydrazide → HCID 12726849, compound

HRID 1763609Notes

Reaction equation

HRID 1763609 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:13][CH:14]=2)=[CH:6][C:7]=1[CH3:8].[C:19]([NH:22][NH2:23])(=O)[CH3:20]>C(O)CCC>[CH3:20][C:19]1[N:3]2[N:4]=[C:5]([C:9]3[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:13][CH:14]=3)[CH:6]=[C:7]([CH3:8])[C:2]2=[N:23][N:22]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 12449558HCID 12449558, compound

Product 1

HCID 12726849HCID 12726849, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

As in Example 36, a mixture of 8.0 g. of 3-chloro-4-methyl-6-(α,α,α-trifluoro-m-tolyl)pyridazine, 4.34 g. of acetylhydrazine in 125 ml. of n-butanol is refluxed for 48 hrs. to give 3.9 g. of product as crystals, m.p. 196°-198° C.

Workup

  1. additionAs in Example 36, a mixture of 8.0 g
  2. customto give 3.9 g

Sources & evidence

ORD record
ord-1cc5603c4d5f45a08b237b971efe3735
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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