1-Butanol → HCID 9971560, compound

HRID 1763616Notes

Reaction equation

HRID 1763616 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1.[C:18]([NH:22][NH2:23])(=O)[CH2:19][CH3:20].C(O)CCC>C(Cl)(Cl)Cl.CCCCCC>[CH2:19]([C:18]1[N:3]2[N:4]=[C:5]([C:8]3[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][CH:13]=3)[CH:6]=[CH:7][C:2]2=[N:23][N:22]=1)[CH3:20]

Participants

5

Reactant 3

HCID 2631-ButanolHCID 79890PropionylhydrazineHCID 124495523-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine

Product 1

HCID 9971560HCID 9971560, compound

Reagents, catalysts & solvents 1

HCID 21585165Chloroform hexaneSolvent

Procedure

A mixture of 5.0 g. of 3-chloro-6-(α,α,α-trifluoro-m-tolyl)pyridazine, 3.40 g. of propionic acid hydrazide and 100 ml. of n-butanol is refluxed for 48 hr. The solvent is removed under vacuum and the residue dissolved in chloroform. The solution is passed through a column of hydrous magnesium silicate and the eluent concentrated to give 3.0 g. of crystals (from CHCl3 -hexane), m.p. 183°-185° C.

Workup

  1. additionA mixture of 5.0 g
  2. customThe solvent is removed under vacuum
  3. dissolutionthe residue dissolved in chloroform
  4. concentrationthe eluent concentrated
  5. customto give 3.0 g

Sources & evidence

ORD record
ord-d8f9abc52a744fbfb1b5aa0ed34737a7
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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