Hydrogen Peroxide → HCID 20310616, compound

HRID 1763637Notes

Reaction equation

HRID 1763637 reaction equation
[F:1][C:2]([F:20])([F:19])[S:3][C:4]1[CH:18]=[CH:17][C:7]2[CH2:8][CH2:9][N:10]3[CH:16]=[CH:15][CH:14]=[C:11]3[C:12](=[O:13])[C:6]=2[CH:5]=1.[OH:21]O>C(O)(=O)C>[F:20][C:2]([F:1])([F:19])[S:3]([C:4]1[CH:18]=[CH:17][C:7]2[CH2:8][CH2:9][N:10]3[CH:16]=[CH:15][CH:14]=[C:11]3[C:12](=[O:13])[C:6]=2[CH:5]=1)=[O:21]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 13141177HCID 13141177, compound

Product 1

HCID 20310616HCID 20310616, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3 gm. of 9-trifluoromethylthio-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one in 25 ml. of acetic acid containing 3 ml. of 50% hydrogen peroxide is stirred at 25° C. for 6 hr. The solvent is evaporated and the residue dissolved in 100 ml. of methylene chloride. The solution is washed with 2 × 25 ml. of 5% Na2CO3 solution, dried and evaporated. Chromatography of the residue on silica gel yields 9-trifluoromethylsulfinyl-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one.

Workup

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved in 100 ml
  3. washThe solution is washed with 2 × 25 ml
  4. dry with materialof 5% Na2CO3 solution, dried
  5. customevaporated

Sources & evidence

ORD record
ord-230aa54e0d1540d89f0eedc660599fcd
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

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