Hydrogen Peroxide → HCID 20310643, compound

Participants

Reaction Steps

A solution of 2 gm. of 9-trifluoromethylsulfinyl-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one in 20 ml. of acetic acid containing 5 ml. of 90% hydrogen peroxide is stirred at 25° C. for 4 days. The solvent is evaporated and the residue dissolved in 100 ml. of methylene chloride. After washing the organic solution with 2 × 25 ml. of 1N Na2CO3, it is dried and evaporated, and the residue chromatographed on silica gel to yield 9-trifluoromethylsulfonyl-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one.

Provenance & Evidence