Hydrogen Peroxide → HCID 20310643, compound

HRID 1763638Notes

Reaction equation

HRID 1763638 reaction equation
[F:1][C:2]([F:21])([F:20])[S:3]([C:5]1[CH:19]=[CH:18][C:8]2[CH2:9][CH2:10][N:11]3[CH:17]=[CH:16][CH:15]=[C:12]3[C:13](=[O:14])[C:7]=2[CH:6]=1)=[O:4].[OH:22]O>C(O)(=O)C>[F:21][C:2]([F:1])([F:20])[S:3]([C:5]1[CH:19]=[CH:18][C:8]2[CH2:9][CH2:10][N:11]3[CH:17]=[CH:16][CH:15]=[C:12]3[C:13](=[O:14])[C:7]=2[CH:6]=1)(=[O:22])=[O:4]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 20310616HCID 20310616, compound

Product 1

HCID 20310643HCID 20310643, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2 gm. of 9-trifluoromethylsulfinyl-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one in 20 ml. of acetic acid containing 5 ml. of 90% hydrogen peroxide is stirred at 25° C. for 4 days. The solvent is evaporated and the residue dissolved in 100 ml. of methylene chloride. After washing the organic solution with 2 × 25 ml. of 1N Na2CO3, it is dried and evaporated, and the residue chromatographed on silica gel to yield 9-trifluoromethylsulfonyl-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one.

Workup

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved in 100 ml
  3. washAfter washing the organic solution with 2 × 25 ml
  4. dry with materialof 1N Na2CO3, it is dried
  5. customevaporated
  6. customthe residue chromatographed on silica gel

Sources & evidence

ORD record
ord-e8fc4604321c47dfbf8ba86cec405cad
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

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