Hydrogen Peroxide → HCID 20310641, compound

HRID 1763646Notes

Reaction equation

HRID 1763646 reaction equation
[F:1][C:2]([F:20])([F:19])[S:3][C:4]1[CH:5]=[C:6]2[N:12]([CH:13]=1)[CH:11]=[CH:10][C:9]1[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=1[C:7]2=[O:18].[OH:21]O>C(O)(=O)C>[F:20][C:2]([F:1])([F:19])[S:3]([C:4]1[CH:5]=[C:6]2[N:12]([CH:13]=1)[CH:11]=[CH:10][C:9]1[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=1[C:7]2=[O:18])=[O:21]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 13154190HCID 13154190, compound

Product 1

HCID 20310641HCID 20310641, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3 gm. of 2-trifluoromethylthio-11H-pyrrolo[2,1-b][3]benzazepin-11-one in 25 ml. of acetic acid containing 3 ml. of 50% hydrogen peroxide is stirred at 25° C. for 6 hrs. The solvent is evaporated and the residue dissolved in 100 ml. of methylene chloride. The solution is washed with 2 × 25 ml. of 5% Na2CO3 solution, dried and evaporated. Chromatography of the residue on silica gel yields 2-trifluoromethylsulfinyl-11H-pyrrolo[2,1-b][3]benzazepin-11-one.

Workup

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved in 100 ml
  3. washThe solution is washed with 2 × 25 ml
  4. dry with materialof 5% Na2CO3 solution, dried
  5. customevaporated

Sources & evidence

ORD record
ord-d2207f5494d143ff931054947f8efdf5
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

Loading…