Acetic Acid → HCID 20310586, compound

HRID 1763648Notes

Reaction equation

HRID 1763648 reaction equation
[C:1]([C:3]1[CH:17]=[CH:16][C:6]2[CH:7]=[CH:8][N:9]3[CH:15]=[CH:14][CH:13]=[C:10]3[C:11](=[O:12])[C:5]=2[CH:4]=1)#[N:2].Cl.C(O)(=[O:21])C>>[C:1]([C:3]1[CH:17]=[CH:16][C:6]2[CH:7]=[CH:8][N:9]3[CH:15]=[CH:14][CH:13]=[C:10]3[C:11](=[O:12])[C:5]=2[CH:4]=1)(=[O:21])[NH2:2]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 131541969-cyano-11H-pyrrolo[2,1-b][3]benzazepin-11-one

Product 1

HCID 20310586HCID 20310586, compound

Procedure

9-Cyano-11H-pyrrolo[2,1-b][3]benzazepin-11-one (30 g., 0.135 mole) in 100 ml. of concentrated hydrochloric acid and 100 ml. of acetic acid is refluxed for 2 hours. It is then poured onto 500 ml. of water and continuously extracted with methylene chloride. The solution is left to cool to room temperature and filtered to afford 9-carbamoyl-11H-pyrrolo[2,1-b][3]benzazepin-11-one.

Workup

  1. additionIt is then poured onto 500 ml
  2. extractionof water and continuously extracted with methylene chloride
  3. waitThe solution is left
  4. filtrationfiltered

Sources & evidence

ORD record
ord-dddde135e641448c8ef0e3b4cc334099
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

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