Acetic Anhydride → HCID 54537209, compound

HRID 1763661Notes

Reaction equation

HRID 1763661 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]2[CH:6]=[CH:7][N:8]3[CH:19]=[CH:18][CH:17]=[C:9]3[C:10](=[CH:11][CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])[C:4]=2[CH:3]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>N1C=CC=CC=1>[C:22]([NH:1][C:2]1[CH:21]=[CH:20][C:5]2[CH:6]=[CH:7][N:8]3[CH:19]=[CH:18][CH:17]=[C:9]3[C:10](=[CH:11][CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])[C:4]=2[CH:3]=1)(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 537550839-amino-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine

Product 1

HCID 54537209HCID 54537209, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

9-Amino-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine (11.4 mmoles) dissolved in 15 ml. pyridine is treated with acetic anhydride (2 ml.) at room temperature for 19 hours. The volatiles are removed under vacuum and the residue is dissolved in chloroform, and chromatographed on silica gel. Elution with chloroform-methanol yields 9-acetamido-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine.

Workup

  1. customThe volatiles are removed under vacuum
  2. dissolutionthe residue is dissolved in chloroform
  3. customchromatographed on silica gel
  4. washElution with chloroform-methanol

Sources & evidence

ORD record
ord-b329555e2517467999cd936365be851d
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

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