Acetic Acid → 2-carbamoyl-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine

HRID 1763662Notes

Reaction equation

HRID 1763662 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[N:11]([CH:12]=1)[CH:10]=[CH:9][C:8]1[CH:13]=[CH:14][CH:15]=[CH:16][C:7]=1[C:6]2=[CH:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])#[N:2].Cl.C(O)(=[O:26])C>>[C:1]([C:3]1[CH:4]=[C:5]2[N:11]([CH:12]=1)[CH:10]=[CH:9][C:8]1[CH:13]=[CH:14][CH:15]=[CH:16][C:7]=1[C:6]2=[CH:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])(=[O:26])[NH2:2]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 53685151HCID 53685151, compound

Product 1

HCID 706269012-carbamoyl-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine

Procedure

2-Cyano-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine (0.135 mole) in 100 ml. of concentrated hydrochloric acid and 100 ml. of acetic acid is refluxed for 2 hours. It is then poured onto 500 ml. of water and continuously extracted with methylene chloride. The solution is left to cool to room temperature and filtered to afford 2-carbamoyl-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine.

Workup

  1. additionIt is then poured onto 500 ml
  2. extractionof water and continuously extracted with methylene chloride
  3. waitThe solution is left
  4. filtrationfiltered

Sources & evidence

ORD record
ord-10568e8f8e7b444b80812d79832b989b
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

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