N-Hydroxysuccinimide → HCID 70617506, compound

HRID 1763671Notes

Reaction equation

HRID 1763671 reaction equation
[OH:1][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][C:3]1=[O:8].[Cl:9][C:10]([Cl:17])([Cl:16])[CH2:11][O:12][C:13](Cl)=[O:14]>N1C=CC=CC=1>[C:3]1(=[O:8])[NH:2][C:6](=[O:7])[CH2:5][CH2:4]1.[C:13](=[O:1])([OH:14])[O:12][CH2:11][C:10]([Cl:17])([Cl:16])[Cl:9]

Participants

4

Reactant 2

HCID 80170N-HydroxysuccinimideHCID 870632,2,2-Trichloroethyl chloroformate

Product 1

HCID 70617506HCID 70617506, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 4.6 gram portion of N-hydroxysuccinimide and 5.5 ml. of 2,2,2-trichloroethylchloroformate in 30 ml. of dry pyridine is reacted as described in Example 2. The product is recrystallized from diethyl ether giving 2,2,2-trichloroethyl carbonate succinimide. A 400 mg. portion of this product and 300 mg. of trans-BM123γ are reacted as described in Example 1 giving 273.9 mg. of trichloroacetyl-trans-BM123γ.

Workup

  1. customThe product is recrystallized from diethyl ether

Sources & evidence

ORD record
ord-9027c3e0c83341e6a27b8a7c1ff484fc
Source dataset
uspto-grants-1978_09
Patent number
US04112219

Reaction notes

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