HCID 54043940, compound → HCID 20310965, compound

HRID 1763700Notes

Reaction equation

HRID 1763700 reaction equation
[OH:1][CH:2]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][C:12]1[CH:13]=[C:14]([CH:20]=[CH:21][CH:22]=1)[CH:15]=[CH:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8]>C(O)C.[Pd]>[OH:1][CH:2]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][C:12]1[CH:13]=[C:14]([CH:20]=[CH:21][CH:22]=1)[CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:8])=[O:9]

Participants

4

Reactant 1

HCID 54043940HCID 54043940, compound

Product 1

HCID 20310965HCID 20310965, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

m-[N-(4-Hydroxynonyl)methanesulfonamidomethyl]-cinnamic acid (3.0 g., 0.075 mole) dissolved in ethanol (80 ml.) is hydrogenated over 0.8 g. of a 5% Pd on charcoal catalyst at one atmosphere of pressure and room temperature. After the theoretical amount of hydrogen is absorbed, the catalyst is removed by filtration. The ethanol is evaporated and the residual solid is purified by crystallization to afford the pure title compound.

Workup

  1. customat one atmosphere of pressure and room temperature
  2. customAfter the theoretical amount of hydrogen is absorbed
  3. customthe catalyst is removed by filtration
  4. customThe ethanol is evaporated
  5. customthe residual solid is purified by crystallization

Sources & evidence

ORD record
ord-54dedb3606f64d90acbc85deb1f9b594
Source dataset
uspto-grants-1978_09
Patent number
US04112236

Reaction notes

Loading…