反应详情

A solution of 7 g. of Nα -benzyloxycarbonyl-D-alanyl-L-leucine, methyl ester in 100 ml. of methanol and 22 ml. of 0.95 l N hydrogen chloride in methanol is stirred with 500 mg. of 20% palladium on carbon catalyst under hydrogen at one inch water pressure until thin layer chromatography of a sample shows complete conversion (three to six hours). The solution is filtered to remove the catalyst and is evaporated to a foam. Solution in chloroform, 50 ml., and precipitation by ethyl ether affords an oil which is collected and dried at 45° C. and 1 mm. pressure. The oil is used in the next step without further purification.

1. customconversion (three to six hours)
2. filtrationThe solution is filtered
3. customto remove the catalyst
4. customis evaporated to a foam
5. custom, and precipitation by ethyl ether
6. customaffords an oil which
7. customis collected
8. customdried at 45° C.
9. customThe oil is used in the next step without further purification