Methanol → HCID 178465181, compound

HRID 1763722Notes

Reaction equation

HRID 1763722 reaction equation
[ClH:1].[CH2:2]([NH:4][C:5](=[O:32])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:31])[C@H:12]([CH2:24][CH2:25][CH2:26][NH:27][C:28](=[NH:30])[NH2:29])[NH:13]C(OCC1C=CC=CC=1)=O)[CH3:3].CO.[H][H]>[Pd].O>[ClH:1].[CH2:2]([NH:4][C:5](=[O:32])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:31])[C@H:12]([CH2:24][CH2:25][CH2:26][NH:27][C:28](=[NH:29])[NH2:30])[NH2:13])[CH3:3]

Participants

6

Reactant 3

HCID 887MethanolHCID 178418361HCID 178418361, compoundHCID 178465168HCID 178465168, compound

Product 1

HCID 178465181HCID 178465181, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A solution of 8.7 g. of Nα -benzyloxycarbonyl-L-arginyl-L-proline N-ethylamide hydrochloride in 100 ml. of methanol is stirred with 500 mg. of 20% palladium on carbon under one inch water pressure of hydrogen for three hours. The catalyst is removed by filtration and the filtrate evaporated under reduced pressure and at 35°-40° C. The residual foam is used without further purification.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe filtrate evaporated under reduced pressure and at 35°-40° C
  3. customThe residual foam is used without further purification

Sources & evidence

ORD record
ord-d822306ecf144b95be274ece79f8a49b
Source dataset
uspto-grants-1978_09
Patent number
US04111923

Reaction notes

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