Acetate → HCID 178465156, compound

HRID 1763723Notes

Reaction equation

HRID 1763723 reaction equation
Cl.[CH2:2]([NH:4][C:5](=[O:86])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:85])[C@H:12]([CH2:78][CH2:79][CH2:80][NH:81][C:82](=[NH:84])[NH2:83])[NH:13][C:14](=[O:77])[C@H:15]([CH2:73][CH:74]([CH3:76])[CH3:75])[NH:16][C:17](=[O:72])[C@@H:18]([CH3:71])[NH:19][C:20](=[O:70])[C@H:21]([CH2:62][C:63]1[CH:68]=[CH:67][C:66]([OH:69])=[CH:65][CH:64]=1)[NH:22][C:23](=[O:61])[C@H:24]([CH2:59][OH:60])[NH:25][C:26](=[O:58])[C@H:27]([CH2:48][C:49]1[C:57]2[C:52](=[CH:53][CH:54]=[CH:55][CH:56]=2)[NH:51][CH:50]=1)[NH:28][C:29](=[O:47])[C@H:30]([CH2:42][CH2:43][C:44](=[O:46])[NH2:45])[NH:31][C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH3:3].C([O-])(=O)C>O>[CH2:2]([NH:4][C:5](=[O:86])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:85])[C@H:12]([CH2:78][CH2:79][CH2:80][NH:81][C:82](=[NH:83])[NH2:84])[NH:13][C:14](=[O:77])[C@H:15]([CH2:73][CH:74]([CH3:76])[CH3:75])[NH:16][C:17](=[O:72])[C@@H:18]([CH3:71])[NH:19][C:20](=[O:70])[C@H:21]([CH2:62][C:63]1[CH:64]=[CH:65][C:66]([OH:69])=[CH:67][CH:68]=1)[NH:22][C:23](=[O:61])[C@H:24]([CH2:59][OH:60])[NH:25][C:26](=[O:58])[C@H:27]([CH2:48][C:49]1[C:57]2[C:52](=[CH:53][CH:54]=[CH:55][CH:56]=2)[NH:51][CH:50]=1)[NH:28][C:29](=[O:47])[C@H:30]([CH2:42][CH2:43][C:44](=[O:46])[NH2:45])[NH:31][C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH3:3]

Participants

4

Reactant 2

HCID 175AcetateHCID 178465157HCID 178465157, compound

Product 1

HCID 178465156HCID 178465156, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 100 mg. of Nα -benzyloxycarbonyl-L-glutaminyl-L-tryptophyl-L-seryl-L-tyrosyl-D-alanyl-L-leucyl-L-arginyl-L-proline N-ethylamide, hydrochloride in a minimal amount of water, 40 to 50 ml., is put on a column of Dowex 1×2 (acetate form) 1.2×37 cm. The material is then eluted with water (150 ml.) and the fractions lyophilized and the Nα -benzyloxycarbonyl-L-glutaminyl-L-tryptophyl-L-seryl-L-tyrosyl-D-alanyl-L-leucyl-L-arginyl-L-proline N-ethylamide acetic acid salt examined by ultraviolet in methanol (λmax 280 E11 56.3) and for chloride. Analysis indicates an acetate salt with 2 CH3COOH and 5 H2O in the molecular formula.

Workup

  1. washThe material is then eluted with water (150 ml.)

Sources & evidence

ORD record
ord-e0d38f71c39b4c0ca52dc122e058927b
Source dataset
uspto-grants-1978_09
Patent number
US04111923

Reaction notes

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