Hydrochloric Acid → HCID 86735998, compound

HRID 1763730Notes

Reaction equation

HRID 1763730 reaction equation
[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH2:24][CH:25]([CH3:27])[CH3:26])[NH:5][C:6](=[O:23])[C@@H:7]([CH2:19][CH:20]([CH3:22])[CH3:21])[NH:8]C(OCC1C=CC=CC=1)=O.[ClH:29].[H][H]>CO.[Pd]>[ClH:29].[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH2:24][CH:25]([CH3:27])[CH3:26])[NH:5][C:6](=[O:23])[C@@H:7]([CH2:19][CH:20]([CH3:22])[CH3:21])[NH2:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 7237625HCID 7237625, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86735998HCID 86735998, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

A solution of 1.95 g. of Nα -benzyloxycarbonyl-D-leucyl-L-leucine methyl ester in 50 ml. of absolute methanol containing 2.08 ml. of 2.38N hydrogen chloride in methanol is treated with 250 mg. of 10% palladium on carbon and is shaken in a hydrogen atmosphere until thin layer chromatography of solution samples indicate completion of the reaction. The catalyst is removed by filtration and the filtrate taken to dryness. The product is used without further purification.

Workup

  1. customcompletion of the reaction
  2. customThe catalyst is removed by filtration
  3. customThe product is used without further purification

Sources & evidence

ORD record
ord-d8ec2595201443de8f2fed78e0af303d
Source dataset
uspto-grants-1978_09
Patent number
US04111923

Reaction notes

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