Diethyl Ether → HCID 20307441, compound

HRID 1763752Notes

Reaction equation

HRID 1763752 reaction equation
[CH:1](=[CH:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4]C=1.[NH:19]1[CH:23]=[N:22][CH:21]=[N:20]1.[CH2:24](OCC)C>>[C:1]1([C:8]([N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)([CH3:24])[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)=[O:10])[CH:2]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 92571H-1,2,4-TriazoleHCID 315896HCID 315896, compound

Product 1

HCID 20307441HCID 20307441, compound

Procedure

Benzal-3', 4'-dichloroacetophenone (13.8 g; 0.05 mol) and 1,2,4-triazole (3.4 g; 0.05 mol) were fused together at 120°-140° for 30 minutes. After cooling to room temperature, diethyl ether (10.0 ml) was added to precipitate the unreacted benzal 3',4'-dichloroacetophenone which was filtered off. The filtrate was concentrated to give a solid residue which, on crystallisation from carbon disulphide/absolute ethanol gave 2-phenyl-2-(1,2,4-triazol-1-yl)-3',4'-dichloropropiophenone (compound 2), m.p. 68°-71° C.

Workup

  1. customto precipitate the unreacted benzal 3',4'-dichloroacetophenone which
  2. filtrationwas filtered off
  3. concentrationThe filtrate was concentrated
  4. customto give a solid residue which
  5. customon crystallisation from carbon disulphide/absolute ethanol

Sources & evidence

ORD record
ord-b7cbd2a16cf64921ba84c1d5cbb3ae2b
Source dataset
uspto-grants-1978_09
Patent number
US04113465

Reaction notes

Loading…