Diethyl Ether → HCID 20307441, compound

Participants

Reaction Steps

Benzal-3', 4'-dichloroacetophenone (13.8 g; 0.05 mol) and 1,2,4-triazole (3.4 g; 0.05 mol) were fused together at 120°-140° for 30 minutes. After cooling to room temperature, diethyl ether (10.0 ml) was added to precipitate the unreacted benzal 3',4'-dichloroacetophenone which was filtered off. The filtrate was concentrated to give a solid residue which, on crystallisation from carbon disulphide/absolute ethanol gave 2-phenyl-2-(1,2,4-triazol-1-yl)-3',4'-dichloropropiophenone (compound 2), m.p. 68°-71° C.

Provenance & Evidence