HCID 20308088, compound → HCID 23332765, compound

HRID 1763846Notes

Reaction equation

HRID 1763846 reaction equation
[C:1]1([C:7]2[S:8][C:9]([NH:18][C:19](=[O:27])NC3C=CC=CC=3)=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(OCC)(=O)C>[C:1]1([C:7]2[S:8][C:9]3[NH:18][C:19](=[O:27])[C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=4[C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 20308088HCID 20308088, compound

Product 1

HCID 23332765HCID 23332765, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
300 °C

Procedure

15 Grams of crude 3-(2,4-diphenylthiazol-5-yl)-1-phenylurea (m.p. 240°-260° C.), prepared following substantially the procedure described in the first part of Example 5, is heated to 300° C. on a metal bath and maintained at this temperature for about 8 minutes. The reaction mass is then cooled and sludged with ethyl acetate. On crystallization from dimethylformamide, 6.95 g of the title compound is obtained. M.p. >310° C.; yield 62%.

Workup

  1. temperaturemaintained at this temperature for about 8 minutes
  2. temperatureThe reaction mass is then cooled
  3. customOn crystallization from dimethylformamide

Sources & evidence

ORD record
ord-b61ab6868d744adbaa1957dc27884750
Source dataset
uspto-grants-1978_09
Patent number
US04113731

Reaction notes

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