Hydrochloric Acid → HCID 86736011, compound

HRID 1763851Notes

Reaction equation

HRID 1763851 reaction equation
[F:1][C@:2]12[C@@H:22]([OH:23])[CH2:21][C@@:20]3([CH3:24])[C@@H:12]([CH2:13][CH:14]=[C:15]3[C:16](=[O:19])[CH2:17][OH:18])[C@@H:11]1[CH2:10][CH2:9][C:8]1[C@:3]2([CH3:26])[CH:4]=[CH:5][C:6](=[O:25])[CH:7]=1.[CH3:27][S:28](Cl)(=[O:30])=[O:29].Cl>N1C=CC=CC=1>[F:1][C@:2]12[C@@H:22]([OH:23])[CH2:21][C@@:20]3([CH3:24])[C@@H:12]([CH2:13][CH:14]=[C:15]3[C:16](=[O:19])[CH2:17][O:18][S:28]([CH3:27])(=[O:30])=[O:29])[C@@H:11]1[CH2:10][CH2:9][C:8]1[C@:3]2([CH3:26])[CH:4]=[CH:5][C:6](=[O:25])[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 70580639HCID 70580639, compound

Product 1

HCID 86736011HCID 86736011, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 16 grams of 9-fluoro-11β,21-dihydroxypregna-1,4,16-triene-3,20-dione in dry pyridine (200 ml) is reacted with methanesulfonyl chloride (5.0 ml) for 2 hours at 0° C. The mixture is poured into an excess of cold 2N-hydrochloric acid. The solid that separates from the resulting solution is isolated yielding 17.5g of the title compound, which is characterized by its nmr spectrum.

Workup

  1. customThe solid that separates from the resulting solution is isolated

Sources & evidence

ORD record
ord-d10cc9d5401944cd993e414222a4a296
Source dataset
uspto-grants-1978_09
Patent number
US04113722

Reaction notes

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