L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)- → L-Glutamine

HRID 1763893Notes

Reaction equation

HRID 1763893 reaction equation
C([NH:8][C@H:9]([C:15]([OH:17])=[O:16])[CH2:10][CH2:11][C:12](=[O:14])[NH2:13])(OC(C)(C)C)=O>CN(C)C=O>[NH2:8][C@H:9]([C:15]([OH:17])=[O:16])[CH2:10][CH2:11][C:12](=[O:14])[NH2:13]

Participants

3

Reactant 1

HCID 83687L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)-

Product 1

HCID 5961L-Glutamine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To the product of Step (D) above there is added with mixing 4 molar excess of the p-nitrophenyl ester of Boc-L-glutamine [Gln (ONp), Peninsula, supra.] dissolved in 15-20 ml. of dimethylformamide containing 1.5 M urea. The resulting mixture is shaken overnight, filtered, washed with dimethylformamide-ethanol mixture and dried.

Workup

  1. dissolutiondissolved in 15-20 ml
  2. filtrationfiltered
  3. washwashed with dimethylformamide-ethanol mixture
  4. customdried

Sources & evidence

ORD record
ord-398e3ee390854c17a9a74ac48275bc76
Source dataset
uspto-grants-1978_09
Patent number
US04113858

Reaction notes

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