Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 44522644, compound

HRID 1763901Notes

Reaction equation

HRID 1763901 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:8][N:9]([CH3:13])[CH2:10]2)=[CH:5][CH:4]=1.OC1C=C2C(C(C3C=CC=CC=3)[CH2:26][N:27]([CH3:31])[CH2:28]2)=CC=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>O>[CH3:26][N:27]([CH2:31][CH2:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:8][N:9]([CH3:13])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:28]

Participants

5

Reactant 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 15113388HCID 15113388, compoundHCID 20308544HCID 20308544, compound

Product 1

HCID 44522644HCID 44522644, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

The title compound was prepared from (+)- 7 -methoxy- 2 -methyl- 4 -phenyl- 1,2,3,4 -terahydro isoquinoline via (+)- 7 -hydroxy- 2 -methyl- 4 -phenyl- 1,2,3,4 -tetrahydro isoquinoline which was characterised as its hydrochloride salt m.p. 222°-3° C. (methanol-ether) [α]D25 + 24.1° (water) by the method of Example 1. The title compound was characterised as its dihydrochloride salt m.p. 160°-4° (hydroscopic) (ethanol ethyl acetate), [α]D5 + 13° (water). -tetrahydro

Sources & evidence

ORD record
ord-3151a928cca449b2a87425ee5be34f54
Source dataset
uspto-grants-1978_09
Patent number
US04113869

Reaction notes

Loading…