Water → HCID 12703747, compound

Participants

Reaction Conditions

Reaction Steps

22.32 g of 3-(p-formylphenyl)-1,2-benzisoxazole, 14.03 g of p-chloroaniline and 0.5 g of boric acid in 160 ml of xylene are refluxed for 2 hours, the water formed being distilled off. The mixture is cooled to 60° C., 500 ml of methanol are added and the resulting mixture is further cooled to -10° C. The product which has precipitated is filtered off with suction, washed with 100 ml of cold methanol and dried. This gives 32 g (96.2% of theory) of compound (102) in the form of pale yellow crystals which melt at 164° to 165° C. After recrystallising twice from toluene, pale yellow crystals with a melting point of 164.5° to 165° C. are obtained.

Provenance & Evidence