Ammonia → Diphenylmethyl α-[(2-amino-2-oxoacetyl)amino]benzeneacetate

HRID 1763943Notes

Reaction equation

HRID 1763943 reaction equation
C([O:3][C:4](=O)[C:5]([NH:7][CH:8]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:9]([O:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])=[O:6])C.[NH3:32]>C(O)C>[NH2:32][C:4](=[O:3])[C:5]([NH:7][CH:8]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:9]([O:11][CH:12]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:10])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86736019HCID 86736019, compound

Product 1

HCID 86736018Diphenylmethyl α-[(2-amino-2-oxoacetyl)amino]benzeneacetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 10mM of DL-α-[(2-ethoxy-1,2-dioxoethyl)-amino]phenylacetic acid, diphenylmethyl ester in 50 ml. of ethanol containing 13mM of ammonia is stirred for 15 minutes. After a short time, a thick slurry forms. The product, DL-α-[(2-amino-1,2-dioxoethyl)amino]phenylacetic acid, diphenylmethyl ester, is filtered off and recrystallized from toluene in the form of white filaments, m.p. 168°.

Workup

  1. filtrationThe product, DL-α-[(2-amino-1,2-dioxoethyl)amino]phenylacetic acid, diphenylmethyl ester, is filtered off
  2. customrecrystallized from toluene in the form of white filaments, m.p. 168°

Sources & evidence

ORD record
ord-bae7143263d74350bedfefff2efa077e
Source dataset
uspto-grants-1978_09
Patent number
US04113943

Reaction notes

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