Ammonia → Diphenylmethyl α-[(2-amino-2-oxoacetyl)amino]benzeneacetate

Participants

Reaction Steps

A mixture of 10mM of DL-α-[(2-ethoxy-1,2-dioxoethyl)-amino]phenylacetic acid, diphenylmethyl ester in 50 ml. of ethanol containing 13mM of ammonia is stirred for 15 minutes. After a short time, a thick slurry forms. The product, DL-α-[(2-amino-1,2-dioxoethyl)amino]phenylacetic acid, diphenylmethyl ester, is filtered off and recrystallized from toluene in the form of white filaments, m.p. 168°.

Provenance & Evidence