Hydrochloric Acid → HCID 20308866, compound

HRID 1763944Notes

Reaction equation

HRID 1763944 reaction equation
[NH2:1][C:2](=[O:29])[C:3]([NH:5][CH:6]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:7]([O:9]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:8])=[O:4].Cl>C(O)(=O)C>[NH2:1][C:2](=[O:29])[C:3]([NH:5][CH:6]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:7]([OH:9])=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86736018Diphenylmethyl α-[(2-amino-2-oxoacetyl)amino]benzeneacetate

Product 1

HCID 20308866HCID 20308866, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

13 g. of the product of Example 12 are added to 250 ml. of a 6N solution of hydrochloric acid in glacial acetic acid. After stirring for 15 minutes everything dissolves. The reaction solution is evaporated at room temperature and the white crystalline residue is triturated with ether, filtered under suction and recrystallized from water to obtain DL-α-[(2-amino-1,2-dioxoethyl)amino]phenylacetic acid as white crystals, m.p. 193°.

Workup

  1. dissolutiondissolves
  2. customThe reaction solution is evaporated at room temperature
  3. customthe white crystalline residue is triturated with ether
  4. filtrationfiltered under suction
  5. customrecrystallized from water

Sources & evidence

ORD record
ord-000079a2dfc64037819f825beb8631fb
Source dataset
uspto-grants-1978_09
Patent number
US04113943

Reaction notes

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