HCID 47862, compound → HCID 12672391, compound

HRID 1763949Notes

Reaction equation

HRID 1763949 reaction equation
C([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=O)C>Cl>[NH2:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15]

Participants

3

Reactant 1

HCID 47862HCID 47862, compound

Product 1

HCID 12672391HCID 12672391, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 25.1 g (0.1 mole) of 5-acetamido 4,7-dimethoxy 6-piperidinoethoxy benzofuran were brought to reflux for 10 hours in 200 ml of 2 N hydrochloric acid. Then it was neutralized with concentrated soda, extracted with ethyl acetate, the solvent was evaporated, the residue was taken up again in acetone and 30 ml of 7 N hydrochloric ethanol were added. It was filtered and recrystallized in ethanol.

Workup

  1. concentrationwith concentrated soda
  2. extractionextracted with ethyl acetate
  3. customthe solvent was evaporated
  4. addition30 ml of 7 N hydrochloric ethanol were added
  5. filtrationIt was filtered
  6. customrecrystallized in ethanol

Sources & evidence

ORD record
ord-12d29312db234a53b3706344a8a8ea0e
Source dataset
uspto-grants-1978_09
Patent number
US04113951

Reaction notes

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