Ethanol → HCID 47862, compound

HRID 1763950Notes

Reaction equation

HRID 1763950 reaction equation
[C:1]([NH:4][C:5]1[C:6]([OH:18])=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2].[N:19]1([CH2:25][CH2:26]Cl)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C(=O)([O-])[O-].[K+].[K+].C(O)C>CC(C)=O>[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:26][CH2:25][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 702EthanolHCID 11430Potassium CarbonateHCID 748271-(2-Chloroethyl)piperidineHCID 12672367HCID 12672367, compound

Product 1

HCID 47862HCID 47862, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A mixture of 25.1 g (0.1 mole) of 5-acetamido 4,7-dimethoxy 6-hydroxy benzofuran, 22.2 g (0.15 mole) of 2-piperidino chlorethane and 41.6 g (0.3 mole) of potassium carbonate in 250 ml of acetone was brought to reflux for 2 hours. Then it was filtered, the solvent evaporated, the residue obtained was taken up again in acetone and 20 ml of 7 N hydrochloric ethanol were added. It was filtered and recrystallized in 400 ml of propanol.

Workup

  1. temperatureto reflux for 2 hours
  2. filtrationThen it was filtered
  3. customthe solvent evaporated
  4. customthe residue obtained
  5. filtrationIt was filtered
  6. customrecrystallized in 400 ml of propanol

Sources & evidence

ORD record
ord-1587bbbfd3cc40f4bc1aacae5a84573b
Source dataset
uspto-grants-1978_09
Patent number
US04113951

Reaction notes

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