huagongshe.com
HRID1764067

反应详情

EQUATION

反应方程式

HRID 1764067 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(Cl)cc1
HCID7812

4-Chloroaniline

C6H6ClN

结构：COC(=O)c1c(C)oc(C)cc1=O
HCID12281371

4H-Pyran-3-carboxylic acid, 2,6-dimethyl-4-oxo-, methyl ester

C9H10O4

PRODUCTS

生成物

1
结构：COC(=O)c1c(C)n(-c2ccc(Cl)cc2)c(C)cc1=O
HCID22769951

未命名化合物

收率 46.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cc1ccc(S(=O)(=O)O)cc1.O
催化剂HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

40 g of 3-carbomethoxy-2,6-dimethylpyr-4-one and 30.2 g of 4-chloroaniline are dissolved in 400 ml of toluene along with 400 mg of p-toluenesulfonic acid monohydrate. The reaction mixture is refluxed for 4 hours. The solvent is removed and the product crystallized from ether to yield 30 g of N-(4-chlorophenyl)-3-carbomethoxy-2,6-dimethylpyrid-4-one (m.p. 189°-90°).

WORKUP

后处理

  1. temperatureThe reaction mixture is refluxed for 4 hours
  2. customThe solvent is removed
  3. customthe product crystallized from ether