Water → HCID 21328367, compound

HRID 1764086Notes

Reaction equation

HRID 1764086 reaction equation
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=1[NH2:9].[F:15][C:16]([F:26])([F:25])[C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH:20]=O.O>C1(C)C(C)=CC=CC=1>[CH3:14][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=1[N:9]=[CH:20][C:19]1[CH:22]=[CH:23][CH:24]=[C:17]([C:16]([F:15])([F:25])[F:26])[CH:18]=1

Participants

5

Reactant 3

HCID 962WaterHCID 679903-(Trifluoromethyl)benzaldehydeHCID 186727122-[3-(Dimethylamino)propoxy]aniline

Product 1

HCID 21328367HCID 21328367, compoundYield 52.6%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 19.4g of 2-(3-dimethylaminopropoxy)aniline and 17.4g of m-trifluoromethylbenzaldehyde in 100ml of xylene is refluxed for about 6 hours. The water formed in the reaction is collected in a Dean-Stark tube. The solvent is removed under reduced pressure and the residue fractionated to yield 18.4g of the title compound as an oil, boiling point 155°-160° C. at 0.2-0.3 mm. of Hg.

Workup

  1. customis collected in a Dean-Stark tube
  2. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-454ccd149fb442e19a8e78d79ef4ebd9
Source dataset
uspto-grants-1978_09
Patent number
US04115382

Reaction notes

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