反应详情

To a solution of 1.6 g of sodium in 100 ml of absolute ethanol, 10 g of p-(1-cyclohexenyl)-phenol in a small amount of absolute ethanol are added at room temperature under anhydrous conditions and with stirring. 25.2 Grams of α-bromo-undecanoic acid ethyl ester are then added dropwise. and the reaction mixture is stirred for 24 hours at 50° C. The ethanol is subsequently stripped off in vacuo and the residue is partitioned between water and ice-cold N solution hydroxide solution. The organic phase is washed until neutral, dried over sodium sulphate and concentrated in vacuo. The residue yields the crude α-[p-(1-cyclohexenyl)-phenoxy]-undecanoic acid ethyl ester of the formula ##STR19## in the form of an oil.

1. stirringand the reaction mixture is stirred for 24 hours at 50° C
2. customthe residue is partitioned between water and ice-cold N solution hydroxide solution
3. washThe organic phase is washed until neutral,
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated in vacuo