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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1764232Generated: October 31, 2026

1-Fluoro-2-nitrobenzene → Methyl 3-(2-nitroanilino)thiophene-2-carboxylate

https://huagongshe.com/reaction/1764232

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Fluoro-2-nitrobenzeneHCID 73895—
ReactantMethyl 3-amino-2-thiophenecarboxylateHCID 89652—
SolventToluene methanolHCID 21867641—
ProductMethyl 3-(2-nitroanilino)thiophene-2-carboxylateHCID 20387689—

Reaction Steps

The title compound was prepared using the process of Example 1(a) but with 2-fluoro-nitrobenzene and methyl 3-aminothiophene-2-carboxylate (U.K. Pat. No. 837,086) as starting materials, m.p. 184° C., (toluene/MeOH, 2:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04115568
Source datasetuspto-grants-1978_09
ORD IDord-d477831edc4542a0bf3d418eb9536e3f
Source noteuspto-grants-1978_09